Fig. 2.

The role of ferroptosis in neurodegenerative diseases. Various inducers and inhibitors of ferroptosis in different neurodegenerative diseases are shown. Inducers of ferroptosis in AD [23, 41], inhibitors of ferroptosis in AD [23]; inducers of ferroptosis in PD [41], inhibitors of ferroptosis in PD [40, 41, 62]; inducers of ferroptosis in HD [42, 69, 70], inhibitors of ferroptosis in HD [69, 70]; inducers of ferroptosis in stroke [22], inhibitors of ferroptosis in stroke [40, 83]. DFO, deferoxamine; Fer-1, ferrostatin-1; RSL3, Ras-selective lethal 3; Lip-1, liproxstatin-1; VE, vitamin E