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. 2022 Jul 22;13:907286. doi: 10.3389/fendo.2022.907286

Figure 2.

Figure 2

Transcripts modulated by NAT10-mediated ac4C modification in oocytes. (A) Venn diagram and pie chart showed the proportion of NAT10-regulated ac4C genes and non–ac4C-modified genes. (B) Box diagram displayed the fold change difference between NAT10-regulated ac4C-modified DEGs and non–ac4C-modified DEGs. (C) Sixteen downregulated ac4C-modified DEGs regulated by NAT10 mainly participated in regulation of protein binding and positive regulation of transcription, DNA-templated. (D) KEGG analysis showed 16 downregulated ac4C-modified DEGs regulated by NAT10 were enriched in cancer, signal transduction, folding, sorting, and degradation. Unpaired t-test was used in (B) to compare the expression of genes because the number of genes did not match between two groups. **P < 0.01.