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. 2022 Jul 22;13:907286. doi: 10.3389/fendo.2022.907286

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Copyright © 2022 Lin, Xiang, Huang, Zeng, Zeng, Liu, Wu, Liang, Liang, Li and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OGA Stability was modulated by NAT10-mediated ac4C modification. (A) Expression of OGA was downregulated significantly by comparing NAT10 KD transcriptome with the control. (B) The diagram displayed ac4C-modified potential sites of OGA in homo sapiens and Mus musculus. (C) Bar chart showed OGA could bind to NAT10 and be ac4C-modified by RIP. (D) The degradation of OGA was suppressed in NAT10-overexpressing compared with negative control group. (E) Immunofluorescence showed NAT10 degradation and OGA downregulation after NAT10 KD by Trim-Away. Data represent the mean ± SEM of at least three independent experiments. *P < 0.05, **P < 0.01, and ***P< 0.001.