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. 2022 Aug 4;12:13447. doi: 10.1038/s41598-022-17823-7

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Interaction networks between differentially expressed genes (DEGs) and relative abundance of microbial strains. (A) Network analysis of 13 advanced colorectal cancer (ACRC) samples and 10 high-risk adenoma (HRA) samples versus 7 normal control (NC) samples. (B) Network analysis of 13 ACRC samples versus 10 HRA samples. (C) Network analysis of 13 ACRC samples versus 7 NC samples. (D) Network analysis of 10 HRA samples and 7 NC samples. Genes that are enriched in the word group are indicated in red; all other genes are in blue. Species with high relative abundance in the word group are indicated in red; all other species are in blue.