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. 2022 Aug 4;13(8):675. doi: 10.1038/s41419-022-05129-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Mass spectrum analysis of significant differential proteins in the supernatant of CAFs and NOFs. B Volcano plot depicted 95 differential proteins which were abundant in CAFs (red spots, log2 ratio > 2, P < 0.05). The bule spots represented the down-regulated proteins. C The top 20 significantly differentiated proteins were listed in the heatmap. CRMP2 (DPYL2, DPYSL2) was marked with a red square frame. D ELISA assay detected the expression of CRMP2 in the supernatant of CAFs and NOFs. E Western blotting analyzed the expression of CRMP2 in CAFs, NOFs, SKOV3, and A2780 cells. Results are presented as the mean ± SD of three independent experiments. ***P < 0.001.