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. 2022 Aug 4;13(8):675. doi: 10.1038/s41419-022-05129-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The tumor xenografts were photographed on the 31st day of the experiment. IgG and neutralization antibody (Ab) were injected intraperitoneally on the second day of every three days. B Tumor volumes were recorded every three days. C Tumor weights were measured at the end of the experiment. D Intraperitoneal metastasis models were conducted. The peritoneal metastatic images were photographed at the end of the experiment, and the representative images of each group were displayed (black dotted circle). E Metastatic tumor weights were recorded. F The number of metastatic foci were calculated. G Immunohistochemistry (IHC) analysis of α-SMA, CRMP2 and HIF-1α in mice tumors of each group. **P < 0.01, ***P < 0.001, ns not significant.