Table 1.

Rate constant values from global fits of data shown in Figure 3A using KinTek Explorer

pH	k +1	k −1	k +2	Kd
7.0	1.35 ± 0.01	49.7 ± 0.3	0.0073 ± 0.0004	36.8 ± 0.4
7.5	1.69 ± 0.01	51.1 ± 0.3	0.0169 ± 0.0005	30.2 ± 0.3
8.0	1.50 ± 0.01	51.2 ± 0.3	0.038 ± 0.006	34.2 ± 0.3
8.5	1.45 ± 0.01	61.7 ± 0.4	0.099 ± 0.001	42.6 ± 0.4
9.0	0.976 ± 0.009	75.1 ± 0.4	0.280 ± 0.003	77.0 ± 0.8