FIGURE 3.

Heatmap of signaling pathways related to proliferation and angiogenesis and the relative importance of each cell group based on the computed network centrality measures of signaling networks. (A) For the heatmap of signaling pathways related to proliferation and angiogenesis. The communication probability of a signaling pathway was computed by summarizing the probabilities of its associated ligand–receptor pairs. The darker the color, the greater the communication probability between the two cell types. (B) For the relative importance of each cell group based on the computed network centrality measures of signaling networks. Influencer represents a kind of cell that can control information flow within a signaling network, and a higher value indicates greater control on the information flow. Gatekeeper represents a kind of cell that can control communication flow between any two cell groups, and a higher value indicates greater capability to control the communication flow. The meaning of importance is the magnitude of the possibility of four roles (sender, receiver, mediator, and influencer) that the cell types play. The darker the color, the greater the role cells play.