Fig. 6.

In vivo anti-tumor activity of MMV-Au-CDs-DOX. (A) Schematic diagram of therapeutic mechanism and the specific treatment process of MMV-Au-CDs-DOX. (B) In vivo distribution of ICR mice with breast cancer lung metastasis treatment with MMV-Au-CDs-ICG. (C) Typical photographs of lungs from mice and (D) the quantitative analysis of tumor necrosis area after treated with saline alone (Group I), DOX alone (Group II), Au-CDs (Group III), Au-CDs-DOX (Group IV) and MMV-Au-CDs-DOX (Group V). (E) The weight changes of mice during the treatment for 15 days. (F) Tumor permeability verification of Au-CDs-DOX and MMV-Au-CDs-DOX via FIM images of 3D 4T1 tumor model. (G) Histological analysis of the lung lesion after treatment with different agents.