Effects of GM-Lipo@ARB on ECM homeostasis. (A, B) Immunofluorescence images of Col II and MMP13 protein. (C) Quantification of Col II and MMP13 fluorescences. (n = 3, # and ∗ indicate P < 0.05 in comparison with the control and IL-1β groups, respectively) (D, E) Immunofluorescence images of Col II and Aggrecan on cells that grew with the microspheres. (F) Quantification of Col II and MMP13 fluorescences on microspheres. (n = 3, ∗ indicate P < 0.05) (G) Western blot of ECM proteins and ECM degrading enzymes. (J) Protein expression result of ECM proteins (i-ii) and ECM degrading enzymes (iii-iv) by semi-quantification (n = 3, # and ∗ indicate P < 0.05 in comparison with the control and IL-1β groups, respectively).