Table 2:
The results of the core lab assessment of coronary atherosclerosis by coronary computed tomography angiography stratified by the median values of high-sensitivity cardiac troponin and interleukin 6.
| Variables | All patients (n=1,796) | ≤Median hs-cTn (≤1.5 ng/l) (n=904) | >Median hs-cTn (>1.5 ng/l) (n=892) | p value | ≤Median IL-6 (≤1.8 ng/l) (n=954) | >Median IL-6 (>1.8 ng/l) (n=842) | p value |
|---|---|---|---|---|---|---|---|
| Coronary plaque – n (%) | |||||||
| Any plaque | 1,177 (65.5) | 543 (60.1) | 634 (71.1) | <0.001 | 617 (64.7) | 560 (66.5) | 0.426 |
| Non-Ca or partially Ca plaque | 1,032 (57.5) | 477 (52.8) | 555 (62.2) | <0.001 | 541 (56.7) | 491 (58.3) | 0.503 |
| Ca plaque | 145 (8.1) | 66 (7.3) | 79 (8.9) | 0.260 | 76 (8.0) | 69 (8.2) | 0.863 |
| High-risk plaque | |||||||
| Any high-risk plaque | 277 (15.4) | 110 (12.2) | 167 (18.7) | <0.001 | 142 (14.9) | 135 (16.0) | 0.513 |
| Positive remodeling | 256 (14.3) | 100 (11.1) | 156 (17.5) | <0.001 | 135 (14.2) | 121 (14.4) | 0.893 |
| Low CT attenuation | 83 (4.6) | 26 (2.9) | 57 (6.4) | <0.001 | 34 (3.6) | 49 (5.8) | 0.024 |
| Napkin ring sign | 60 (3.3) | 26 (2.9) | 34 (3.8) | 0.295 | 33 (3.5) | 27 (3.2) | 0.794 |
| Coronary stenosis – n (%) | |||||||
| No stenosis | 619 (34.5) | 361 (39.9) | 258 (28.9) | <0.001 | 337 (35.3) | 282 (33.5) | 0.007 |
| 1–29% stenosis | 549 (30.6) | 267 (29.5) | 282 (31.6) | 315 (33.0) | 234 (27.8) | ||
| 30–49% stenosis | 380 (21.2) | 188 (20.8) | 192 (21.5) | 189 (19.8) | 191 (22.7) | ||
| 50–69% stenosis | 132 (7.4) | 56 (6.2) | 76 (8.5) | 66 (6.9) | 66 (7.8) | ||
| 70–100% stenosis | 116 (6.5) | 32 (3.5) | 84 (9.4) | 47 (4.9) | 69 (8.2) | ||
| Any stenosis ≥70% or LM ≥50% | 118 (6.6) | 34 (3.8) | 84 (9.4) | <0.001 | 47 (4.9) | 71 (8.4) | 0.003 |
| Any stenosis ≥50% – n (%) | 248 (13.8) | 88 (9.7) | 160 (17.9) | <0.001 | 113 (11.8) | 135 (16.0) | 0.011 |
| CAD-RADS categories | <0.001 | 0.006 | |||||
| CAD-RADS 0 | 569 (31.7) | 330 (36.5) | 239 (26.8) | 313 (32.8) | 256 (30.4) | ||
| CAD-RADS 1 | 599 (33.4) | 298 (33.0) | 301 (33.7) | 339 (35.5) | 260 (30.9) | ||
| CAD-RADS 2 | 380 (21.2) | 188 (20.8) | 192 (21.5) | 189 (19.8) | 191 (22.7) | ||
| CAD-RADS 3 | 130 (7.2) | 54 (6.0) | 76 (8.5) | 66 (6.9) | 64 (7.6) | ||
| CAD-RADS 4a | 98 (5.5) | 27 (3.0) | 71 (8.0) | 43 (4.5) | 55 (6.5) | ||
| CAD-RADS 4b and 5 | 20 (1.1) | 7 (0.8) | 13 (1.5) | 4 (0.4) | 16 (1.9) | ||
| Coronary plaque burden | |||||||
| Coronary calcium score | |||||||
| AS Median (IQR) | 20.7 (0.0–175.9) | 9.1 (0.0–107.7) | 35.5 (0.0–249.3) | <0.001 | 19.3 (0.0–154.9) | 24.7 (0.0–214.7) | 0.142 |
| Mean ± SD | 190.8 ± 507.8 | 133.8 ± 395.5 | 249.6 ± 596.7 | 185.9 ± 521.0 | 196.3 ± 492.5 | ||
| AS 0 – n (%) | 559/1,575 (35.5) | 319/800 (39.9) | 240/775 (31.0) | <0.001 | 308 (36.7) | 251 (34.1) | 0.128 |
| AS 1–100 – n (%) | 512/1,575 (32.5) | 276/800 (34.5) | 236/775 (30.5) | 275 (32.8) | 237 (32.2) | ||
| AS 101–300 – n (%) | 229/1,575 (14.5) | 103/800 (12.9) | 126/775 (16.3) | 127 (15.1) | 102 (13.9) | ||
| AS >300 – n (%) | 275/1,575 | 102/800 | 173/775 (22.3) | 129 (15.4) | 146 (19.8) | ||
| Segment involvement score | |||||||
| Median (IQR) | 2 (0–5) | 1 (0–4) | 2 (0–5) | <0.001 | 2 (0–4) | 2 (0–5) | 0.187 |
| Mean ± SD | 2.8 ± 3.0 | 2.3 ± 2.7 | 3.2 ± 3.2 | 2.6 ± 2.9 | 2.9 ± 3.1 | ||
| Leaman score | |||||||
| Median (IQR) | 3.7 (0–8.5) | 3.2 (0–7.4) | 4.8 (0–9.6) | <0.001 | 3.4 (0–8.0) | 4.0 (0–9.0) | 0.117 |
| Mean ± SD | 5.0 ± 5.1 | 4.2 ± 4.7 | 5.8 ± 5.3 | 4.8 ± 4.9 | 5.2 ± 5.3 |
Abbreviations: SD standard deviation; IQR interquartile range (25th to 75th percentile); Ca calcified; LM left main coronary artery; AS Agatston score