TABLE 2.
REDS-IV-P Study Portfolio and Study Categories
| Study category | Patient population | Study title | Linked donor-recipient study | Analysis of existing database(s) | Database queried |
|---|---|---|---|---|---|
| Transfusion epidemiology | Pediatrics | Epidemiology of Neonatal Transfusion | No | Yes | REDS-III patient database (7 hospitals, 2013–20169) |
| Epidemiology of Pediatric Transfusion | No | Yes | REDS-III patient database (11 hospitals, 2013–201610) | ||
| Transfusion in Pediatric Hematology/Oncology and Stem Cell Transplant | No | Yes | REDS-III patient database (11 hospitals, 2013–201611) | ||
| Transfusion in Pediatric Cardiac Surgery | No | Yes | REDS-III patient database (3 hospitals, 2013–201612) | ||
| Transfusion in Pediatric Craniosynostosis and Neurosurgery | No | Yes | REDS-III patient database (4 hospitals, 2013–2016) | ||
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| Transfusion recipient outcomes | Pediatrics | Transfusion in Preterm infants (TIPI) Studyc | Yes | Yes | REDS-IV-P-V2V database and VON database (8 hospitals, 2019–2022) |
| Adults | Donor Genetic and Non-Genetic Factors Affecting Red Blood Cell Transfusion Effectiveness | Yes | Yes | REDS-III-RBC-Omics and REDS-III V2V (4 Blood Centers 2013–201613) | |
| ABO-Incompatible Platelet Transfusions and Associations with Adult Recipient Morbidity and Mortality | Yes | Yes | REDS-III patient database (12 hospitals, 2013–2016) | ||
| Adults and Pediatrics | RBC-IMProving trAnsfusions for Chronically Transfused Recipients with SCD (RBC-IMPACT) (Domestic)† | Yes | No | ||
| The Brazil SCD Cohort Study: Blood Utilization and Patient outcomes | Yes | No | |||
| RBC-IMProving trAnsfusions for Chronically Transfused Recipients with SCD (RBC-IMPACT) – Nested study within the Brazil SCD cohort study | Yes | ||||
| Standardized Echocardiography to Characterize Tricuspid Regulation and Pulmonary Hypertension in Chronically Transfused Patients with SCD - Nested study within the Brazil SCD cohort study | No | ||||
| Rh variants and Unexplained Antibody Study in Patients with SCD - Nested study within the Brazil SCD cohort study | Yes | ||||
| Recipient iron Biomarkers to investigate Transfusion Iron Overload Study - Nested study within the Brazil SCD cohort study | Yes | ||||
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| Rapid response to new blood safety issues | Adults | SARS-CoV-2 studies - REDS-IV-P Epidemiology, Surveillance, and Preparedness of the Novel SARS-CoV-2 Epidemic (RESPONSE) (Domestic)a | No | No | |
| Blood Donor Arbovirus Surveillance Study (Brazil)a | No | ||||
| REDS-IV-P HIV Studies - Monitoring HIV Incidence in the Context of Anti-retroviral Treatment (ART) or Pre-exposure Prophylaxis (PrEP) Therapies (Brazil)a | No | ||||
| The Blood Safety Implications and Advancing Testing for Screening Donors with HIV Infections Taking Antiretroviral (ART) and Pre-exposure Prophylaxis (PrEP) Therapies Studya | No | ||||
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| Blood component quality | Adults | Donor RBC Storage Characteristics Study | Yesd | Yesb | REDS-III RBC-Omics and REDS-III V2V (4 Blood Banks, 12 hospitals, 2013–2016) |
| Core Facility Standardization of RBC Biotin-Labeling: A Tool for Researchers to Perform RBC Survival Studies | Yes | No | |||
a
Blood donor study only.
b
New data added to enrich existing database(s).
c
Databases in collaboration with Non- REDS-IV-P investigators - TIPI_Response_PTMA.
d
The conduct of the linked aspect of this study is contingent upon ongoing donation-based laboratory studies.