Figure 1.

Effect of MDSC on Helper T cell and Helper T cell subset responses. Frequency of Helper T cells (CD3+CD4+) and Helper T cell subsets from in vitro T cell co-culture of autologous T cells (CD3+ cells), MDSC (HLA-CD33+ cells) and control monocytes (HLA+ cells) isolated from PBMC of individuals with active TB disease (n = 7). Plots show individual T cell replicates. Panels (A-D) D’Agostino & Pearson test measured normality. Repeated measures one way ANOVA with Sidak’s multiple comparisons test (parametric data) and Friedman test (non-parametric data). P<0.05 was considered significant.