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. 2022 Jul 22;13:883886. doi: 10.3389/fimmu.2022.883886

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Copyright © 2022 Leukes, Malherbe, Hiemstra, Kotze, Roos, Keyser, De Swardt, Gutschmidt, Walzl and du Plessis

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Sildenafil on the frequency of (A) Total MDSC, (B) M-MDSC, (C) PMN-MDSC, gated as a frequency of PBMC, from in vitro cultures of MDSC (HLA-CD33+ cells) and Control Monocytes isolated from PBMC of individuals with active TB disease (n = 7). Plots show individual TB patient data. D’Agostino and Pearson normality Test. Paired t test (parametric data) and Wilcoxon matched pairs signed rank test (non-parametric data). Median with interquartile range indicated on plots. P<0.05 was considered significant.