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. 2022 Jul 22;13:883886. doi: 10.3389/fimmu.2022.883886

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Copyright © 2022 Leukes, Malherbe, Hiemstra, Kotze, Roos, Keyser, De Swardt, Gutschmidt, Walzl and du Plessis

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sildenafil supplementation does not affect T cell or MDSC cytokine production (IL2, TNFb, GMCSF, IFNg, TNFa). Analyte concentration (pg/ml) was measured for various culture combinations (MDSC only, MDSC-T cell coculture, and T cell only), under differing stimulation combinations (Unstimulated and anti-CD3CD28 bead Activation) with or without Sildenafil treatment, by multiplex analysis. Plots show analyte concentration in culture supernatant. One-way ANOVA with Tukey post-hoc correction. Median with interquartile range indicated on plots. P<0.05 was considered significant. Pairwise comparisons which were ns are not shown on plot.