TABLE 1.

Summary of used bovine WGBS profiles.

Profile	Tissue	Accession number	Source	Breed	Data coverage rate (%)	Methylation rate (%)
Sperm	Sperm	GSE106538	Gamete	Holstein	21.34	74.11
MamGl	Mammary gland	GSE106538	Somatic	Holstein	12.6	73.59
PreCor	Prefrontal cortex	GSE106538	Somatic	Holstein	9.94	84.16
WBC1	White blood cell	GSE106538	Somatic	Holstein	15.38	81.22
WBC2	White blood cell	GSE147087	Somatic	Holstein	13.04	86.53
Adip1	Adipose	GSE147087	Somatic	Holstein	7.98	82.5
Adip2	Adipose	GSE147087	Somatic	Hereford	1.09	94.04
Muscle	Muscle	GSE147087	Somatic	Holstein	7.99	79.1
Heart1	Heart	GSE147087	Somatic	Holstein	1.32	80.44
Heart2	Heart	GSE147087	Somatic	Hereford	0.85	92.47
Lung	Lung	GSE147087	Somatic	Holstein	7.09	78.53
Spleen	Spleen	GSE147087	Somatic	Holstein	11.5	83.85
Liver1	Liver	GSE147087	Somatic	Holstein	5.46	83.27
Liver2	Liver	GSE147087	Somatic	Hereford	0.88	88.6
Ileum	Ileum	GSE147087	Somatic	Holstein	8.69	79.6
Rumen	Rumen	GSE147087	Somatic	Holstein	5.18	59.92
Jejun	Jejun	GSE147087	Somatic	Hereford	1.17	81.84
Kidn1	Kidney	GSE147087	Somatic	Hereford	1.28	88.31
Kidn2	Kidney	GSE147087	Somatic	Holstein	5.69	84.03
Uterus	Uterus	GSE147087	Somatic	Holstein	6.09	84.91
Ovary	Ovary	GSE147087	Somatic	Holstein	11.1	73.01
Placenta	Placenta	GSE147087	Somatic	Hereford	0.98	40.81
GVO	GV Oocyte	GSE121758	Gamete	Holstein	0.16	4.3
MIIO1	MII Oocyte	GSE121758	Gamete	Holstein	0.06	8.39
MIIO2	MII Oocyte a	GSE121758	Gamete	Holstein	0.13	5.05
2-Cell	Embryo	GSE121758	Embryo	Holstein	0.26	2.41
4-Cell	Embryo	GSE121758	Embryo	Holstein	0.21	3.32
8-Cell	Embryo	GSE121758	Embryo	Holstein	0.18	1.97
16-Cell	Embryo	GSE121758	Embryo	Holstein	1.47	5.94

^aIn vitro oocyte. All other oocytes and embryos are in vivo.