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. 2022 Jul 22;9:925389. doi: 10.3389/fmolb.2022.925389

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Copyright © 2022 Yao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical applications of circRNAs in thyroid cancer. CircRNAs are extracted from cell, blood, biopsy and exosome from TC patients. RNA sequencing, microarray, single-cell RNA-seq, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) assays are methods that can be used to detect circRNA levels. CircRNAs are significantly associated with many clinicopathologic characteristics of TC and with TC patient survival parameters, rendering them potential diagnostic and prognostic biomarkers for TC. Overexpression or knockdown of target circRNAs resulting from delivery may serve as potential therapeutic approaches for TC.