Skip to main content
. 2022 Jul 22;9:925389. doi: 10.3389/fmolb.2022.925389

TABLE 1.

Expression profiling of circRNAs in thyroid cancer.

CircRNA (circBase ID or alternative titles based on the gene name or its position on a chromosome) Samples GEO database Methods Identi fied circR NAs Differen tially express ed Upregula ted circRNAs Downreg ulated circRNAs Ref.
CircRNAs that are upregulated (↑) in thyroid cancer samples compared to control
1) hsa_circ_0061406 (circTIAM1) Tissues GSE168449 RNA-seq + qRT- PCR in 60 PTC and ANT / 50 25 25 Zhang et al. (2022)
PTC ANT
3 3
2) hsa_circ_0002360 (circRUNX1) Tissues / RNA-seq + qRT- PCR in 52 PTC and ANT / 100 100 / Chu et al. (2021)
PTC ANT
3 3
3) hsa_circ_0102272 Tissues / RNA-seq + qRT- PCR for 58 TC patients / 54 35 19 Liu et al. (2020b)
TC ANT
5 5
4) circRNA-UMAD1 Serum RNA-seq / 392 208 184 Yu et al. (2020)
Invasive TC TC
2 2
5) hsa_circ_104566 (hsa_circ_0004458) Tissues GSE93522 Microarray + qRT-PCR for PTC and ANT samples / 98 88 10 Peng et al. (2017)
6) hsa_circ_104565 (hsa_circ_0002111) PTC ANT
7) hsa_circ_104595 (hsa_circ_0008016) 6 6
8) hsa_circ_103110 (hsa_circ_0004771)
9) hsa_circ_105038 (hsa_circ_0091894)
10) hsa_circ_400064 (hsa_circ_0092315)
11) hsa_circ_104268 (hsa_circ_0078738)
12) hsa_circ_103307 (hsa_circ_0064557) PTC BTL
13) hsa_circ_001379 (hsa_circ_0000516) 6 6
14) hsa_circ_101356 (hsa_circ_0004846)
15) hsa_circ_102002 (hsa_circ_0003505)
16) hsa_circ_104433 (hsa_circ_0081342)
17) hsa_circ_0000277 Tissues GSE173299 Microarrays + qRT-PCR for 57 PTC and ANT patients / 158 74 84 Guo et al. (2021)
18) hsa_circ_0074530 PTC ANT
19) hsa_circ_0057691 3 3
20) hsa_circRNA000121 Tissues / Microarrays + qRT-PCR / 690 400 290 Yang et al. (2020c)
21) hsa_circRNA051239 Invasive PTMC PTMC
22) hsa_circRNA001059 13 13
23) hsa_circRNA102116
24) hsa_circRNA000466
25) circ_0004053 Tissues GSE93522 Microarrays / 137 115 22 Qiu et al. (2021)
26) circ_0028198 PTC ANT
6 6
27) hsa_circ_007293 Exosomes (serum) / Microarrays + qRT-PCR / 22 3 19 Yang et al. (2019)
28) hsa_circ_031752 PTC BTL
3 3
29) chr20:20425608‑20472956‑ Tissues / RNA-seq + qRT- PCR in 45 PTC and ANT patients / 53 45 8 Guo et al. (2020a)
30) chr5:161330882‑161336769‑ PTC ANT
31) chr7:22308338‑22318037 5 5
32) hsa_circ_0082002
33) hsa_circ_0002111
34) hsa_circ_0008796
35) chr7: 116695750–116700284+ Tissues GSE171011 RNA-seq + qRT- PCR 16569 720 301 419 Lv et al. (2021)
36) chr7:116699071–116700284+ PTC ANT
37) chr5: 161330883–161336769− 4 4
38) chr4: 25665378–25667298+
39) chr1: 12578718–12579412−
40) hsa_circ_0124055 Tissues / RNA-seq + qRT-PCR for 66 TC patients / 231 133 98 Sun et al. (2020b)
41) hsa_circ_0101622 TC ANT
5 5
42) hsa_circ_0004458 Tissues GSE93522 Microarrays and RNA-Seq / 14 14 / Liu et al. (2020d)
PTC ANT
6 6
43) chr5:160757890-160763776− Tissues / RNA-seq + qRT- PCR for 87 PTC patients 9103 87 41 46 Lan et al. (2018b)
44) chr12:40696591-40697936+ PTC ANT
45) chr7:22330794-22357656− 3 3
46) chr21:16386665-16415895−
47) hsa_circRNA_007148 Tissues / Microarrays + qRT-PCR for 40 PTC patients / 383 206 177 Ren et al. (2018)
PTC ANT
3 3
48) hsa_circ_406841 FRO cell line / Microarrays + qRT-PCR / 50 25 25 Hou et al. (2018)
49) hsa_circ_00905 AGPS sh and KO groups compared with the control group
50) hsa_circ_019252
51) hsa_circ_089761
52) hsa_circ_006050
53) hsa_circ_074298
54) hsa_circ_066556
55) hsa_circ_101321
56) hsa_circ_023016
57) hsa_circ_019744
CircRNAs that are downregulated (↓) in thyroid cancer samples compared to control
1) hsa_circ_IPCEF1 Tissues GSE173299 Microarrays + qRT-PCR for 57 PTC and ANT / 158 74 84 Guo et al. (2021)
PTC ANT
3 3
2) hsa_circ_0077514 (circHACE1) Tissues GSE93522 Microarrays + qRT-PCR / 20 10 10 Li et al. (2021b)
PTC ANT
6 6
3) hsa_circ_0007694 Tissues / qRT-PCR + RNA-seq in 3 PTC and ANT / 129 87 42 Long et al. (2020)
PTC ANT
12 12
4) hsa_circ_100777 (hsa_circ_0021553) Tissues GSE93522 Microarray + qRT-PCR for PTC and ANT samples / Peng et al. (2017)
5) hsa_circ_100395 (hsa_circ_0015278) PTC ANT 98 88 10
6) hsa_circ_104348 (hsa_circ_0079891) 6 6
7) hsa_circ_103454 (hsa_circ_0067103) PTC BTL 355 129 226
6 6
8) hsa_circ_0020396 Tissues GSE173299 Microarrays + qRT-PCR for 57 PTC and ANT patients / 158 74 84 Guo et al. (2021)
9) hsa_circ_0095448 PTC ANT
10) hsa_circ_IPCEF1 3 3
11) hsa_circ_0021549
12) hsa_circRNA404686 Tissues / Microarrays + qRT-PCR / 690 400 290 Yang et al. (2020d)
13) hsa_circRNA001729 Invasive PTMC PTMC
14) hsa_circRNA404686 13 13
15) hsa_circRNA004183
16) hsa_circRNA102051
17) hsa_circRNA405571
18) hsa_circ_020135 Exosomes (serum) / Microarrays + qRT- PCR / 22 3 19 Yang et al. (2019)
PTC BTL
3 3
19) hsa_circ_0072309 Tissues / RNA-seq + qRT- PCR in 45 PTC and ANT / 53 45 8 Guo et al. (2020a)
PTC ANT
5 5
20) chr5: 38481299–38530666 Tissues GSE171011 RNA-seq + qRT- PCR 16569 720 301 419 Lv et al. (2021)
21) chr2: 159932176–159945082− PTC ANT
22) chr10: 179994–249088+ 4 4
23) chr3: 121378716–121381532+
24) chr1: 237423092–237445522+
25) hsa_circ_0067934 Tissues GSE93522 Microarrays and RNA-Seq / 14 14 / Liu et al. (2020d)
26) hsa_circ_0000673 PTC ANT
6 6
27) chr22:36006931-36007153− Tissues / RNA-seq + qRT- PCR for 87 PTC patients 9103 87 41 46 Lan et al. (2018b)
28) chr7:91924203-91957214+ PTC ANT
29) chr2:179514891-179516047− 3 3
30) chr9:16435553-16437522− 3 3
31) hsa_circRNA_047771 Tissues / Microarrays + qRT-PCR for 40 PTC patients / 383 206 177 Ren et al. (2018)
PTC ANT
3 3
32) hsa_circ_404686 FRO cell line / Microarrays + qRT-PCR / 50 25 25 Hou et al. (2018)
33) hsa_circ_00367 AGPS sh and KO groups compared with the control group
34) hsa_circ_001729
35) hsa_circ_004183
36) hsa_circ_100790
37) hsa_circ_104270
38) hsa_circ_102049
39) hsa_circ_406494
40) hsa_circ_100787
41) hsa_circ_082319

Abbreviations: PTC:papillary thyroid cancer, ANT: adjacent non-tumor tissue, BTL:benign thyroid lesion, PTMC: papillary thyroid microcarcinoma, qRT-PCR: quantitative reverse transcriptase-polymerase chain reaction, RNA-Seq: RNA sequencing. AGPS: alkylglycerone phosphate synthase, sh: short hairpin, KO:knockout.