TABLE 2.
Clinical significance of dysregulated circRNAs in thyroid cancer.
| Circular RNAs | Associated clinicopathological characteristics | Diagnostic value | Prognostic value | Ref. |
|---|---|---|---|---|
| CircRNAs that are upregulated (↑) in thyroid cancer samples compared to control | ||||
| 1) circRUX1 | tumour size, lymphnode metastasis, TNM stage, extrathyroidal extension | / | / | Chu et al. (2021) |
| 2) hsa_circ_0004458 | tumour size, lymphnode metastasis, TNM stage, distant metastasis | / | / | Jin et al. (2018) |
| 3) ciRS-7 | tumour size, lymphnode metastasis | / | / | Han et al. (2020a) |
| 4) circEIF3I | tumour size, lymphnode metastasis, TNM stage | / | / | Wang et al. (2020b) |
| 5) circPSD3 | tumour size, lymphnode metastasis, TNM stage | / | / | Zhu et al. (2021) |
| 6) circFOXM1 | tumour size, TNM stage, nodular goiter | / | undifferentiated OS; DFS | Ye et al. (2020) |
| 7) circBACH2 | tumour size, lymphnode metastasis, TNM stage | diagnosing TC (AUC=0.882) | OS | Cai et al. (2019) |
| 8) circ_0079558 | tumour size, TNM stage | Zheng et al. (2021a) | ||
| 9) circ_FNDC3B | tumour size, lymphnode metastasis, TNM stage | diagnosing TC (AUC=0.891) | OS | Wu et al. (2020a) |
| 10) circ_0067934 | tumour size, lymphnode metastasis, TNM stage | / | OS: an independent factor (RR=4.385) | Wang et al. (2019a) |
| 11) circ_0001666 | lymphnode metastasis | / | / | Qi et al. (2021b) |
| 12) hsa_circ_102002 | lymphnode metastasis, TNM stage | / | OS | Zhang et al. (2021c) |
| 13) hsa_circ_0001018 | lymphnode metastasis, TNM stage, distant metastasis | / | / | Luo et al. (2021) |
| 14) hsa_circ_0008274 | lymphnode metastasis, TNM stage, tumour infiltration | / | poor prognosis of TC | Ma and Kan (2021) |
| 15) circPRMT5 | lymphnode metastasis | / | / | Xue et al. (2020) |
| 16) circ_0011058 | lymphnode metastasis, TNM stage, nodular goiter | / | / | Zhang et al. (2021d) |
| 17) circUBAP2 | lymphnode metastasis, TNM stage | / | OS | Xiong et al. (2021b) |
| 18) circPUM1 | lymphnode metastasis, TNM stage | / | OS | Li et al. (2021d) |
| 19) hsa_circ_0002111 | lymphnode metastasis, TNM stage | diagnosing TC (AUC=0.833) | / | Du et al. (2021) |
| 20) circZFR | lymphnode metastasis, TNM stage, extrathyroidal extension | / | OS | Wei et al. (2018) |
| 21) hsa_circ_0058124 | / | diagnosing TC (AUC=0.674) | / | Shi et al. (2020) |
| 22) circ_RAPGEF5 | / | diagnosing TC (AUC=0.7684) | / | Shi et al. (2020) |
| 23) hsa_circ_0011290 | / | / | OS | Hu et al. (2020b) |
| 24) hsa_circ_0102272 | TNM stage, histological grade, lymph node metastasis | / | hsa_circ_0102272 high expression was correlated with poor OS and PFS | Liu et al. (2020b) |
| 25) hsa_circ_0124055 | tumour size, TNM stage, histological grade, lymphnode metastasis | hsa_circ_0124055 distinguish TC (AUC=0.836), it combined with hsa_circ_0101622 provide diagnostic value (AUC=0.911) | OS | Sun et al. (2020b) |
| 26) hsa_circ_0101622 | tumour size, TNM stage, histological grade, lymphnode metastasis | diagnosing TC (AUC=0.805) | OS | Sun et al. (2020b) |
| 27) circPVT1 | tumour size, TNM stage, lymphnode metastasis | / | / | Zeng et al. (2021) |
| 28) hsa_circRNA_007148 | lymph node metastasis | diagnosing TC (AUC=0.846) | / | Ren et al. (2018) |
| 29) circ_0059354 | TNM stage, lymph node metastasis | Li et al. (2022) | ||
| 30) circ_0067934 | tumour size, tumour stage, lymphatic metastasis | / | / | Dong et al. (2022) |
| 31) circ_0000144 | tumour size, TNM stage, lymph node metastasis | / | / | Fan et al. (2020) |
| 32) circRNA NRIP1 | TNM stage | / | / | Li et al. (2021a) |
| 33) hsa_circ_007293 | lymphnode metastasis, TNM stage | / | / | Lin et al. (2021) |
| 34) circ_0000644 | tumour size, lymphnode metastasis | / | / | Nie et al. (2022) |
| 35) circ-PRKCI | lymph node metastasis and recurrence | / | / | Liu et al. (2021b) |
| 36) hsa_circ_0058124 | advanced TNM stage, tumour size, extrathyroidal extension, lymph node metastasis, and distant metastasis | / | / | Yao et al. (2019) |
| 37) circRNA UMAD1 | side location, capsular invasion, vascular invasion, lymphnode metastasis, T stage, multifocality | diagnosing PTC with LNM (AUC=0.718) | / | Yu et al. (2020) |
| 38) circRNA_103598 | tumour size, TNM stage, metastasis status | diagnosing PTC (AUC=0.9465) | OS | Zhang et al. (2020b) |
| CircRNAs that are downregulated (↓) in thyroid cancer samples compared to control | ||||
| 1) circHACE1 | tumour size, lymphnode metastasis, TNM stage | / | / | Li et al. (2021b) |
| 2) hsa_circ_0137287 | tumour size, lymphnode metastasis, TNM stage | diagnosing TC (AUC=0.897); predicting extrathyroidal | / | Lan et al. (2018a) |
| 3) circ_ITCH | lymphnode metastasis, TNM stage | / | / | Wang et al. (2018b) |
| 4) hsa_circ_IPCEF1 | lymphnode metastasis | diagnosing TC (AUC=0.801) | / | Guo et al. (2021) |
| 5) combination of circRAPGEF5 and hsa_circ_0058124 | no significant associations (such as age, gender, multifocality), correlate with lymphnode metastasis, TNM stage, distant metastasis | diagnosing TC (AUC=0.807) | / | Shi et al. (2020) |
| 6) circ_0015278 | extrathyroidal invasion, pTstage, pN stage, pTNM stage, a reduced relapse | diagnosing TC (AUC=0.903) | prolonged DFS: an independent factor | Ding et al. (2021a) |
| 7) circNEURL4 | lymphnode metastasis, TNM grade | / | OS | Ding et al. (2021b) |
| 8) hsa_circRNA_047771 | BRAF V600E mutation, lymph node metastasis, TNM stage | diagnosing TC (AUC=0.876) | / | Ren et al. (2018) |
Abbreviations: OS: Overall survival; DFS: Disease-free survival; PFS: Progressive-free survival; RR: Relative risk; HR: Hazard ratio; pN: pathological node; pTNM: pathological tumour-node-metastasis.