Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 22;13:911164. doi: 10.3389/fimmu.2022.911164

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Mei, Fan, Liu, Zhao, Huang, Wei, Hu, Xie, Wang, Ai, Liang, Xu and Guo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Neutralizing antibody responses in mice vaccinated by dTK-S. (A) Pseudovirus neutralization titers were determined for sera collected 2 weeks after dTK-S boost immunization. A 50% reduction relative to the uninfected control wells was shown as pseudovirus NT50. (B) Neutralization activities of the sera from the second dose of dTK-S vaccination against rVSV-eGFP-SARS-CoV-2. (C) VLP neutralization activities of sera from the second dose of dTK-S vaccination. (D) Neutralization activities of the sera from the second dose of dTK-S vaccination against SARS-CoV-2. (E) Neutralization activities of sera from the second dose of dTK-S vaccination for pseudoviruses carrying spike proteins of the SARS-CoV-2 Wuhan strain (WH-S) B.1.351 or B.1.617.2. (F) Neutralization activities of sera from the immunized mice for pseudoviruses carrying spike protein of the SARS-CoV-2 Wuhan strain (WH-S), B.1.351, or carrying single mutations K417N, E484K, N501Y, or D614G. (G) Neutralization activities of sera from the second dose of dTK-S vaccination for pseudoviruses carrying spike proteins of the SARS-CoV-2 Wuhan strain (WH-S) or B.1.1.529. Dotted lines indicate the lower limit of detection (LLOD). Animals with a response at or below the LLOD were put on LLOD. Statistical differences as determined by Student’s t-tests are indicated by asterisks; *p < 0.05, **p < 0.01; ***p < 0.001. dTK-S, vaccinia virus-expressing spike protein; VLP, virus-like particle.