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. 2022 Jul 22;13:934982. doi: 10.3389/fphar.2022.934982

TABLE 1.

Triterpenoids with antitumor action on different cell lines.

Triterpenes Tumor cell Target References
Ganoderic acid -Mk, -S, -Mf, -R, Mc, -T, -Me Lung: 95D, LLC MMP 2/9 Chen et al. (2008), Chen et al. (2010); Li et al. (2013)
Ganoderic acid -A, -F, -H, -Me Breast: MDA-MB-231 AP-1, NF-κB, uPA, Cdk4 Jiang et al. (2008); Li et al. (2012)
Ganoderic acid -X, -T, -E, -B Liver: HuH-7 , SMMC7721, HepG2 ERK, JNK Li et al. (2005); Tang et al. (2006); Hsu et al. (2008); Weng et al. (2008)
Ganoderic acid -T, -Me Colon: HCT-116, HCT-8, Ls174t NFκB-α, MMP-9, uPA, iNOS Chen et al. (2010); Xu et al. (2010)
Ganoderic acid -D Cervical: HeLa AHA1, Cytokeratin 19, Cytokeratin 1, PRDX3 Yue et al. (2008)
Ganoderic acid -DM Prostate: PC-3, LnCaP MMP-2 MMP-9 Johnson et al. (2010)
IL-1, IL-6, TNF-α, CCL-2/MCP-1
Lucidenic acid -C, -A, -N, -B. Leukemia: HL 60 Bcl-2, caspase-9, caspase-3 Hsu et al. (2008)