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. 2022 Jul 22;13:914969. doi: 10.3389/fimmu.2022.914969

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Copyright © 2022 Styles, Gangadhara, Reddy, Sahoo, Shiferaw, Welbourn, Kozlowski, Derdeyn, Velu and Amara

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DM-UFO significantly delays acquisition of SHIV1157ipd3N4 in Mamu-A*01- RMs. (A) Kaplan-Meier plot depicting the number of challenges required to infect control RMs divided by Mamu-A*01 status in control animals. (B) Kaplan-Meier plot depicting the number of challenges required to infect all animals, including vaccinate and unvaccinated Mamu-A*01 and Mamu-A*01- RMs. (C) Kaplan-Meier plot depicting the number of challenges required to infect vaccinated and unvaccinated Mamu-A*01- RMs. (D) Kaplan-Meier plot depicting the number of challenges required to infect vaccinated and unvaccinated Mamu-A*01+ RMs. (E) Correlation between the number of challenges to infection and the total Env specific IFNγ+ CD8 T cell, total Env specific TNFα+ CD8 T cell, and total SHIV specific IFN γ+ CD4 T cell responses post MVA2 and MVA1.