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. 2022 Jul 31;64(4):640–653. doi: 10.5187/jast.2022.e40

Table 2. Influence of DON on expression of tight junction proteins in epithelial cells and pigs intestine tissue.

Study Samples DON concentration Effects Reference
In vitro IPEC-1 0.2 to 2 µM Reduction of ZO-1 protein in higher concentration [7]
IPEC-J2 0.2 to 2 µM Reduction of ZO-1 protein in higher concentration [7]
IPEC-1 10, 30 µM Claudin-3,4 reduced at high concentration of DON [52,56]
IPEC-J2 2 µM Decreased ZO-1, occludin and claudin-3 expressions [57]
In vivo Pigs jejunum 2.85 mg/kg feed 40% decrease of claudin-4 expression [52]
Pigs ileum 3.5 mg/kg feed mRNA expression of claudin-3 and 4 and occluding were decreased [58]
Pigs jejunum 1.006 mg/kg feed Decreased claudin-4 expression [13]
Pigs ileum 3 mg/kg feed Decreased expression of E-cadherin and occluding junction proteins [43]

DON, deoxynivalenol; IPEC-1, intestinal porcine epithelial cell line-1.