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. 2022 Jul 31:10.1111/jebm.12483. Online ahead of print. doi: 10.1111/jebm.12483

TABLE 2.

Meta‐analyses of symptoms of COVID‐19

No. Symptoms Number of SRs Pooled prevalence LCI UCI p Value
1 Cough 68 53.60% 52.10% 55.10% 0.000
2 Fever 68 64.60% 61.30% 67.90% 0.000
3 Diarrhea 63 8.10% 7.30% 9.10% 0.000
4 Headache 58 11.10% 9.00% 13.80% 0.000
5 Muscle soreness 56 18.70% 16.30% 21.30% 0.000
6 Fatigue 52 29.40% 27.50% 31.30% 0.000
7 Dyspnea 50 19.80% 18.20% 21.60% 0.000
8 Sore throat 47 12.40% 9.80% 15.70% 0.000
9 Vomiting 42 5.50% 4.70% 6.30% 0.000
10 Nausea 37 6.70% 6.00% 7.40% 0.000
11 Expectoration 32 23.40% 21.60% 25.30% 0.000
12 Dizziness 28 7.20% 5.30% 9.70% 0.000
13 Tachypnea 26 21.20% 19.80% 22.60% 0.000
14 Abdominal pain 26 3.70% 2.80% 4.80% 0.000
15 Rhinorrhea 24 7.00% 6.10% 8.00% 0.000
16 Ageusia 23 17.40% 12.50% 23.80% 0.000
17 Anorexia 21 12.90% 10.00% 16.60% 0.000
18 Anosmia 20 18.70% 12.20% 27.40% 0.000
19 Nasal congestion 19 5.10% 3.90% 6.80% 0.000
20 Hemoptysis 18 1.80% 1.20% 2.80% 0.000
21 Chest pain 17 5.80% 4.60% 7.40% 0.000
22 Chest distress 14 12.70% 8.90% 17.90% 0.000
23 Chillness 14 10.60% 8.00% 13.90% 0.000
24 Malaise 10 12.10% 7.00% 19.90% 0.000
25 Confusion 10 6.40% 4.10% 9.90% 0.000
26 Arthralgia 8 7.50% 5.20% 10.80% 0.000
27 Rash 8 14.00% 6.80% 26.60% 0.000
28 Tachycardia 6 2.10% 1.70% 2.70% 0.000
29 Chilblains‐like 5 24.60% 12.20% 43.30% 0.010
30 Livedo 5 4.60% 3.30% 6.50% 0.000
31 Conjunctivitis 5 5.50% 2.90% 10.20% 0.000
32 Pharyngeal erythema 4 12.10% 8.00% 17.80% 0.000
33 Hypoxia 4 4.00% 0.40% 29.50% 0.007
34 Urticaria 4 16.80% 14.30% 19.70% 0.000
35 Sneeze 3 4.40% 0.50% 29.60% 0.006
36 Rigor 3 2.00% 0.10% 37.80% 0.025
37 Hypothermia 3 24.80% 8.70% 53.20% 0.079
38 Delirium 3 17.50% 15.20% 20.10% 0.000
39 Constipation 3 5.50% 5.20% 5.80% 0.000
40 Papulosquamous 3 5.80% 1.70% 18.20% 0.000
41 Erythematous 3 33.90% 21.20% 49.40% 0.043
42 Pruritic 3 41.30% 17.20% 70.30% 0.569
43 Cyanosis 3 2.00% 0.30% 11.30% 0.000
44 Conjunctival congestion 3 3.80% 0.90% 13.90% 0.000
45 Eye pain 3 6.90% 1.90% 22.60% 0.000
46 Blurred vision 3 1.20% 0.00% 26.50% 0.011
47 Wheezing 2 16.90% 15.40% 18.60% 0.000
48 Chickenpox‐like Vesicles 2 16.20% 13.50% 19.40% 0.000
49 Petechia 2 3.50% 0.90% 12.50% 0.000
50 Edematous 2 6.90% 3.70% 12.30% 0.000
51 Vesicular 2 11.80% 7.80% 17.40% 0.000
52 Dry eyes 2 14.50% 12.20% 17.20% 0.000
53 Eye itching 2 9.20% 4.80% 16.80% 0.000
54 Photophobia 2 4.80% 2.00% 11.00% 0.000
55 Chemosis 2 4.50% 3.90% 5.30% 0.000
56 Lid edema 2 1.60% 0.60% 4.20% 0.000
57 Dysphonia 1 12.40% 8.30% 18.10% 0.000
58 Belching 1 0.20% 0.10% 0.40% 0.000
59 Dysacousis 1 1.60% 0.00% 97.60% 0.301
60 Drowsiness 1 42.60% 32.70% 53.20% 0.169
61 Numbness 1 5.80% 0.20% 65.40% 0.110
62 Insomnia 1 1.80% 0.20% 12.00% 0.000
63 Syncope 1 5.60% 4.30% 7.20% 0.000
64 Back pain 1 10.00% 9.50% 10.60% 0.000
65 Otalgia 1 4.00% 1.20% 12.30% 0.000
66 Heartburn 1 3.60% 3.40% 3.80% 0.000
67 Hematemesis 1 9.10% 8.80% 9.50% 0.000
68 Melena 1 5.30% 5.00% 5.60% 0.000
69 Hematochezia 1 0.60% 0.50% 0.70% 0.000
70 Goosebumps 1 13.50% 11.70% 15.50% 0.000
71 Pustule 1 1.80% 0.20% 12.00% 0.000
72 Scales 1 7.40% 2.80% 18.10% 0.000
73 Ulcer 1 1.80% 0.20% 12.00% 0.000
74 Tearing 1 12.80% 10.80% 15.10% 0.000

SR, systematic review; LCI, lower 95% confidence intervals; UCI, upper 95% confidence intervals.