Table 3.
The comparison of the anti‐SARS‐CoV‐2 antibodies in each vaccine group
| Variable | AstraZeneca | COVAXIN | Sinopharm | Sputnik V | Total | p value | |
|---|---|---|---|---|---|---|---|
| Anti‐SARS‐CoV‐2 nucleocapsid antibody, (%) | Positive | 4 (25) | 11 (39) | 7 (24) | 15 (15) | 37 (21) | 0.005* |
| Negative | 12 (75) | 17 (61) | 20 (69) | 86 (85) | 135 (78) | ||
| Borderline | 0 | 0 | 2 (7) | 0 | 2 (18) | ||
| Anti‐SARS‐CoV‐2 nucleocapsid antibody, median (IQR) | 0.23 (0.76) | 0.68 (1.57) | 0.47 (0.9) | 0.17 (0.46) | 0.29 (0.65) | 0.000** | |
| Neutralizing antibody (DiaZist), (%) | Positive | 16 (100) | 8 (57) | 16 (80) | 35 (97) | 75 (87) | 0.000* |
| Negative | 0 | 6 (43) | 2 (10) | 1 (3) | 9 (10.5) | ||
| Borderline | 0 | 0 | 2 (10) | 0 | 2 (2) | ||
| Neutralizing antibody titer (DiaZist), median (IQR) | 104.9 (14) | 37.7 (88) | 48.5 (85) | 94.55 (53) | 87.05 (75) | 0.000** | |
| Neutralizing antibody (PishtazTeb), (%) | Positive | 13 (81) | 10 (36) | 20 (69) | 86 (85) | 129 (74) | 0.000* |
| Negative | 3 (19) | 17 (60) | 9 (31) | 15 (15) | 44 (25) | ||
| Borderline | 0 | 1 (4) | 0 | 0 | 1 (0.6) | ||
| Neutralizing antibody titer (PishtazTeb), median (IQR) | 0.1 (0.29) | 0.93 (0.68) | 0.6 (0.97) | 0.09 (0.41) | 0.15 (0.81) | 0.000** | |
| Anti‐SARS‐CoV‐2‐spike antibody, 34 (%) | Positive | 16 (100) | 19 (68) | 27 (93) | 101 (100) | 163 (94) | 0.000* |
| Negative | 0 | 6 (21) | 1 (3.5) | 0 | 7 (4) | ||
| Borderline | 0 | 3 (11) | 1 (3.5) | 0 | 4 (2) | ||
| Anti‐SARS‐CoV‐2‐spike antibody titer, median (IQR) | 7.21 (0.45) | 4.63 (5.99) | 6.35 (3.7) | 7.43 (1.33) | 7.19 (2.39) | 0.000** | |
Note: The instruction of each ELISA kit comes as follows: The anti‐nucleocapsid and anti‐spike antibodies are considered positive with serum levels >1.1 AU/ml, and 0.9–1.1 AU/ml is considered as borderline. Neutralizing antibody measured by DiaZist ELISA kit considered positive if >11 AU/ml. Neutralizing antibody measured by Pishtazteb ELISA kit considered positive if the test result is less than 0.78 OD (i.e., equal to 2.5 µg/ml concentration of neutralizing antibody).
Abbreviations: ELISA, enzyme‐linked immunosorbent assay; IQR, interquartile range; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2; OD, optical density.
*
Pearson Chi‐Square.
**
Kruskal–Wallis test.