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. 2022 Jun 2;9(22):2201734. doi: 10.1002/advs.202201734

Figure 5.

Figure 5

a) Schematic illustration of constructing a supramolecular prodrug nanoplatform from HA‐CD and adamantine‐conjugated heterodimers of JQ1 and Ppa (AD‐SS‐JQ1, AD‐SS‐Ppa) via the host–guest interaction. Schematic diagram of b) the glucose metabolism in tumor cells, JQ1 down‐regulated the expression of c) HK2, d) LDHA, and e) PD‐L1. The synergic therapy promoted f) DCs maturation and g) increased the population of effective memory T lymphocytes, demonstrating effective inhibition of h) abscopal tumor growth and i) lung metastasis. Reproduced under the terms of the Creative Commons CC‐BY license.[ 136 ] Copyright 2021, The Authors. Published by Wiley‐VCH.