Figure 9.

a,b) Schematic illustration of SPNs coated with membranes from 4T1 cells and DCs (SPNE) for PTT‐mediated immunotherapy. c) 4T1 cells were treated with DOX to expose CRT on the membrane surface and DCs were stimulated with resiquimod to provide T cell binding moieties (MHCI, CD80/86). d) The tumor temperature changes under 1064 nm laser irradiation after 24 h administration of SPNE. SPNU were controls without coating cell membranes. e) PTT up‐regulated the expression of HMGB1 in the tumor cytoplasm to induce ICD. f,g) Flow cytometric plots of mature DCs and cytotoxic T cells in lymph nodes after PTT. h) SPNE activated central memory T cells for the long‐term antitumor immunity. Reproduced with permission.^{[ 158 ]} Copyright 2021, Wiley‐VCH.