Figure 13.

a) Schematic illustration of acidity and MMP‐2 dual‐responsive prodrug vesicles (MPV) for co‐delivery of OXA and a photosensitizer. 2,3‐dimethylmaleic anhydride (DMMA) was used to modify hexadecyl‐oxaliplatin diethylene amine (HOA) to form an OXA prodrug (HOAD) and the photosensitizer was conjugated with PEG via an MMP‐2‐labile GPLGLAG peptide. b) MPV‐HOAD switched from a negative charge to a positive one at pH 6.5 in the presence of MMP‐2. ICD induced by OXA and PDT resulted in c) CRT exposure on the tumor cell surface and d) secretion of IFN‐γ. e,f) The multi‐modality therapy activated the immune system of mice for long memory immune responses and protected them from re‐challenge of CT26 and 4T1 live tumor cells. Reproduced with permission.^{[ 182 ]} Copyright 2019, Wiley‐VCH.