TABLE 1.

The causality of blood lead level and Alzheimer’s disease (AD) risk by two-sample Mendelian randomization (MR) analysis using the data of AD consortium (Kunkle et al., 2019).

SNP	Position	Effect allele	GWAS of blood lead level		GWAS of AD		Model	MR analysis		Heterogeneity test		Horizontal pleiotropy
			Beta	P-value	Beta	P-value		Beta	P-value	Cochran’s Q	P-value	Intercept	P-value
rs76153987	chr3:9214817	T	−0.195	4 × 10–6	−0.073	0.0266
							IVW	0.245	0.0103	2.161	0.34
rs116864947	chr7:11705786	T	−0.431	3 × 10–7	−0.123	0.0376						−0.029	0.44
							WME	0.262	0.0367	0.684	0.41
rs6462018	chr7:27519118	G	−0.084	4 × 10–6	−0.002	0.8994