TABLE 2.

The causality of blood lead level and AD risk by two-sample MR analysis using the data of EFO_0000249.

SNP	Position	Effect allele	GWAS of blood lead level		GWAS of AD		Model	MR analysis		Heterogeneity test		Horizontal pleiotropy
			Beta	P-value	Beta	P-value		Beta	P-value	Cochran’s Q	P-value	Intercept	P-value
rs76153987	chr3:9214817	T	−0.195	4 × 10–6	−0.036	0.4025
							IVW	0.242	0.0046	3.297	0.51
rs116864947	chr7:11705786	T	−0.431	3 × 10–7	0.128	0.0333
rs6462018	chr7:27519118	G	−0.084	4 × 10–6	−0.005	0.8136						–0.026	0.385
rs798338	chr7:78287721	A	−0.111	4 × 10–6	−0.015	0.4901
							WME	0.220	0.0059	2.269	0.52
rs10121150	chr9:113369415	C	−0.143	3 × 10–8	0.069	0.0183