TABLE 3.

Correlation and linear regression analysis of prothrombin time (PT), activated partial thromboplastin (APTT), hemoclot thrombin inhibitor (HTI) with drug concentration measured by HPLC-MS in healthy subjects.

Methods	Correlation analysis				Linear regression analysis
Time		2 h	8 h	12 h		2 h	8 h	12 h
APTT	r	0.80**	0.40**	0.36**	Beta	0.24	–0.04	–0.02
	p	5.41E–28	0.90E–4	7.90E-5	t	2.40	–0.61	–0.22
					p	0.02*	0.55	0.82
PT	r	0.38**	0.21*	0.13	Beta	–0.08	0.12	0.03
	p	1.90E–5	0.03	0.16	t	–1.16	1.92	0.51
					p	0.25	0.06	0.61
HTI	r	0.94**	0.84**	0.80**	Beta	0.49	0.64	0.77
	p	5.97E–55	3.97E–32	1.48E–27	t	4.57	7.70	9.84
					p	0.20E–3**	7.64E–12**	9.13E–17**

HTI, hemoclot thrombin inhibitor; APTT, activated partial thromboplastin; PT, prothrombin time; **Correlation is significant at the 0.01 level (2-tailed); *Correlation is significant at the 0.05 level (2-tailed). r means correlation coefficient.