Table 3.
Subgroup analysis for hazard ratios of severe hypoglycemia by reproductive factors for subgroup aged <65, and ≥65 in postmenopausal women with type 2 diabetes mellitus
| Subgroup | RLS, yr | No. of subjects | No. of SH event | Follow-up duration, person-year | Incidence rate, /1,000 person-year | HR (95% CI)a | P for interaction |
|---|---|---|---|---|---|---|---|
| Age, yr | 0.0032 | ||||||
| <65 | <30 | 10,490 | 455 | 85,499.5 | 5.3 | 1 (Ref) | |
| 30–34 | 34,372 | 1,199 | 281,346.4 | 4.3 | 0.83 (0.74–0.92) | ||
| 35–39 | 38,296 | 1,078 | 313,943.3 | 3.4 | 0.69 (0.62–0.77) | ||
| ≥40 | 7,490 | 221 | 61,229.0 | 3.6 | 0.64 (0.54–0.75) | ||
| ≥65 | <30 | 17,640 | 1,837 | 131,540.8 | 14.0 | 1 (Ref) | |
| 30–34 | 39,738 | 3,797 | 299,080.3 | 12.7 | 0.93 (0.88–0.99) | ||
| 35–39 | 26,607 | 2,202 | 203,366.2 | 10.8 | 0.85 (0.80–0.90) | ||
| ≥40 | 6,630 | 490 | 51,043.5 | 9.6 | 0.79 (0.71–0.87) |
RLS, reproductive life span; SH, severe hypoglycemia; HR, hazard ratio; CI, confidence interval.
a
Adjusted for age, fasting glucose level, RLS, number of parities, duration of breastfeeding, duration of hormone replacement therapy, duration of oral contraceptives use, alcohol consumption, smoking, regular exercise, income, body mass index, hypertension, dyslipidemia, chronic kidney disease, use of three or more oral hypoglycemic agents, use of insulin secretagogues such as sulfonylureas and glinides, insulin treatment.