Figure 9.

Cytotoxicity, hemolytic, and in vivo G. mellonella toxicity of alpha mangostin. (A–D) Cellular toxicity of alpha mangostin against liver-derived HEPG2 and lung-derived A549 cell lines showed that the LD₅₀ values (p < 0.05) as16 μg/ml. (E) Hemolysis of human blood red cells (hRBCs) showed the HL₅₀ of alpha mangostin was 16 μg/ml. Vancomycin was used as a negative control and Triton-X (0.0025-1%) was used as a positive control (F) The toxicity of alpha mangostin tested in G. mellonella model showed that >70% of larvae survived at the higher concentration of 16 mg/kg until 120 h (p<0.05). Data represent the mean ± SD (n = 3) for 5 A-E and n=16 larvae per group for 5F.