Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 22;10:861916. doi: 10.3389/fcell.2022.861916

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhou, Matskova, Zheng, Wang, Wang, Xiao, Mo, Wölke, Li, Zheng, Huang, Zhang and Ernberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

LSD1 inhibits the transcription of pro-inflammatory genes in NPC-derived cell lines. (A) LSD1 ChIP analysis of IL6 and IL8 promoter occupancy in C666-1 cell. The bar graph represents fold enrichment in the LSD1 antibody binding to the IL6 and IL8 promoters after the treatment of NPC cell line C666-1 with LSD1 inhibitor at 6 nM, PGN at 1 µg/ml, or together overnight, in relation to IgG binding. (B) Real-time RT-qPCR analysis of proinflammatory gene expression in HK1 and HONE1 cells before and after the treatment with LSD1 inhibitor overnight and followed by stimulation with PGN for two hours *p < 0.05; **p < 0.01; ***p < 0.001.