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. 2022 Jul 22;13:914645. doi: 10.3389/fgene.2022.914645

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Copyright © 2022 Chen, Wang, Huang, Hu and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The immune cell infiltration analysis of substantia nigra between PD patients and healthy controls. (A) The landscape of immune cell infiltration in PD and healthy controls. There were eleven immune cells with significant difference (neutrophil, mast cell, T follicular helper cell, plasmacytoid dendritic cell, MDSC, natural killer T cell, type 1 helper cell, effector memory CD8 T cell, immature B cell, immature dendritic cell, and CD 56 bright natural killer cell). (B) Principal component analysis for immune cell infiltration in PD and healthy controls. (C) Venn diagram of genes screened via WGCNA and immune-related genes dataset. ns, p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001.