FIGURE 1.

Biogenesis and biological functions of circ-ZNF609. (A) ZNF609 is located in chromosome 15q22.31 in humans; the red line indicates its approximate location. ZNF609 contains 10 exons, and the exon2 is spliced in reverse to form circ-ZNF609. The total length of circ-ZNF609 is 874nt and contains a 753nt coding region, the promoter of circ-ZNF609 is at position 128, and the terminator is at position 6. (B) Circ-ZNF609 as a molecular sponge to adsorb microRNAs, reducing its binding to the 3′ UTR of the target mRNA, and regulate gene expression. (C) Circ-ZNF609 can be translated into a protein.