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. 2022 Jul 22;12:940001. doi: 10.3389/fonc.2022.940001

Figure 6.

Figure 6

Improvement of the TMZ activity in combination with p28. (A), Treatment schedule of Groups 1-5. Athymic mice bearing human GBM U-118 cells were randomized into five groups; PBS (control), TMZ 5 mg/kg (=25.7 μmol/kg), p28 10 mg/kg (=3.4 μmol/kg) i.p., and combinations. (B), U-118 xenograft tumor growth curve. N=7/group, Mean+SD. (C). Formalin-fixed tumor sections were stained with H&E and TUNEL (apoptosis). (D). TUNEL-positive cells were counted in each group. **P<0.01 (ANOVA).