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. 2022 Jul 22;12:927706. doi: 10.3389/fonc.2022.927706

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Copyright © 2022 Mo, Hu, Yang, Li, Bashir, Nai, Ma, Jia and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of a regulatory axis of lncRNA–miRNA–mRNA. (A) lncRNA MIR31HG bound to 17 miRNAs. (B, C) Venn diagram identifying the downstream targets in miR-206 and miR-193a-3p, respectively, from miRDB and TargetScan databases. (D) The expression of TNFRSF21 was investigated by GEPIA database. (E) Lots of H3K27Ac marks existed in the promoter region of MIR31HG from the UCSC web server. (F, G) MIR31HG expression in lung adenocarcinoma (LUAD) specimens relative to normal tissues as detected by qRT-PCR and The Cancer Genome Atlas cohort. (H) MIR31HG expression in LUAD specimens relative to normal tissues as detected by GSE130740 cohort. (I) MIR31HG expression in different LUAD cell lines (A549, NCI-H2009, and PC9) compared with bronchial epithelioid cell (HBE) was estimated by qRT-PCR. (J) The overall survival time of patients with LUAD was measured by Kaplan–Meier analysis. ^* p < 0.05; ^** p < 0.01; ^*** p < 0.001.