Table 3.
Intraoperative parameters in the patients with and without renal dysfunction
|
|
CKD stage
|
P
value
|
|
|
RD (EGFR < 60), n = 128
|
Non-RD (EGFR ≥ 60), n = 672
|
||
| Intraoperative variables | |||
| Operative time (min) | 323.0 ± 125.0 | 329.0 ± 108.0 | 0.70 |
| Blood loss (mL) | 380.0 ± 3230.1 | 425.0 ± 1577.3 | 0.42 |
| Procedure of resection | |||
| Anatomical resection | 99 (77.3) | 498 (74.1) | 0.44 |
| Nonanatomical resection | 29 (22.7) | 174 (25.9) | - |
| Resected liver weight (g) | 239.0 ± 459.3 | 252.0 ± 630.0 | 0.57 |
| Curability | |||
| A + B | 117 (91.4) | 563 (83.8) | < 0.05 |
| C | 11 (8.6) | 109 (16.2) | - |
| Tumor characteristics | |||
| Tumor size (cm) | 4.5 ± 3.9 | 4.4 ± 4.6 | 0.85 |
| Tumor number | 1.0 ± 1.7 | 1.0 ± 2.8 | 0.55 |
| PStage1 | |||
| I | 8 (6.3) | 53 (7.9) | 0.11 |
| II | 62 (48.4) | 272 (40.5) | - |
| III | 40 (31.3) | 207 (30.8) | - |
| IV | 18 (14.1) | 140 (20.8) | - |
| Pathological grade | |||
| Well | 24 (18.7) | 95 (14.1) | 0.29 |
| Mod-por | 104 (81.3) | 577 (85.9) | - |
| Vascular invasion1 | |||
| Yes | 11 (8.6) | 145 (21.6) | < 0.001 |
| No | 117 (91.4) | 527 (78.4) | - |
| Liver fibrosis score2 | |||
| 0-1 | 44 (34.4) | 143 (21.2) | < 0.0001 |
| 2 | 43 (33.6) | 172 (25.6) | - |
| 3 | 22 (17.2) | 149 (22.2) | - |
| 4 | 19 (14.8) | 208 (31.0) | - |
1
Liver Cancer Study Group of Japan, 6th edition.
2
Liver fibrosis was graded and staged according to the New Inuyama classification system as follows: F1 (periportal expansion), F2 (porto-portal septa), F3 (porto-central linkage or bridging fibrosis), and F4 (cirrhosis).
P values were determined by the χ2 test or the Mann-Whitney U test. The liver fibrosis score was assessed by expert pathologists using a noncancerous lesion from the resected specimen. RD: Renal dysfunction; CKD: Chronic kidney disease; EGFR: Estimated glomerular filtration rate.