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. 2022 Jul 22;9:963455. doi: 10.3389/fmolb.2022.963455

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Copyright © 2022 Xu, Song, Peng, Yang, Liu, Pei, Guo, Liu, Liu, Li, Li and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Choosing an appropriate soft threshold (power) and building a hierarchical clustering tree (A) The choice of the soft threshold enables the scale-free topology to achieve an exponent of 0.90, and the average connectivity for 1–20 soft threshold powers is analyzed (B) M2 macrophage-related genes with similar expression patterns were merged into the same module using a dynamic tree-cutting algorithm, creating a hierarchical clustering tree. Heatmap of correlations between (C) modules and immune-infiltrating cells (traits).