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. 2022 Jul 22;13:948457. doi: 10.3389/fimmu.2022.948457

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Copyright © 2022 Zhu, Xing, Zhang, Zhang, Shen, Chen, Shen, Jiang, Yuan, Zhang, Wang, Wu, Zhou, Wu, Deng, Liu, Zhang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diabetes alters gene expression in microglia. Bioinformatic analysis on a study, in which the reticular microglia isolated from diabetic (4 weeks) versus non-diabetic mice were compared (GEO139276). (A) The principal component analysis (PCA) plot. (B, C) Heat map (B) and volcano plot map (C) to show the differentiated genes. (D) Pathway analysis showing that the most different expressing gene clusters between the reticular microglia from diabetic versus non-diabetic mice were innate immune response, inflammatory response, and regulation of inflammatory response (blue arrowheads).