Table 3.
Observed versus estimated lung cancer detection rates at 12 months for individual computed tomography lung cancer screening findings (all scans, T0+)
| LR Category | Category Findings | Cases (n) | Prevalence (%) | Lung Cancer at 12 mo (n) | Lung Cancer Detection Rates |
||||
|---|---|---|---|---|---|---|---|---|---|
| Observed (%) | 95% CI (%) | Estimated by LR (%) | Observed vs. Estimated | ||||||
| Negative | 1 | No lung nodules, nodule(s) w/fat or characteristically benign calcifications | 2,784 | 25.5 | 1 | <0.1 | 0–0.2 | <1 | √ |
| Benign | 2 | Solid nodule(s) < 6 mm at baseline, solid nodule(s) < 4 mm new, part-solid nodule(s) < 6 mm total diameter at baseline, nonsolid nodule(s) (GGN) < 30 mm at baseline, nonsolid nodule(s) (GGN) slowly growing, nodules unchanged for >3 mo | 6,320 | 58.0 | 1 | <0.1 | 0–0.09 | <1 | √ |
| 2i | Findings characteristic of infection/inflammation* | 782 | 7.2 | 9 | 1.2 | 0.5–2.2 | N/A | N/A | |
| Total LR2 | 7,102 | 65.2 | 10 | 0.1 | 0.07–0.3 | <1 | √ | ||
| Probably benign | 3 | Lymph nodes 10–15 mm without pulmonary nodules* | 92 | 0.8 | 0 | 0.0 | 0–3.9 | N/A | N/A |
| Solid nodule(s) ⩾ 6 to <8 mm at baseline | 203 | 1.9 | 4 | 2.0 | 0.5–5.0 | 1–2 | √ | ||
| New solid nodule(s) 4 to <6 mm | 145 | 1.3 | 0 | 0.0 | 0–2.5 | ↓ | |||
| Part solid nodule(s) ⩾ 6 mm total diameter w/solid component < 6 mm | 47 | 0.4 | 0 | 0.0 | 0–7.6 | ↓ | |||
| New part-solid nodule(s) < 6 mm total diameter | 35 | 0.3 | 0 | 0.0 | 0–10.0 | ↓ | |||
| Nonsolid nodule(s) (GGN) ⩾ 30 mm at baseline CT | 1 | 0.0 | 0 | 0.0 | 0–97.5† | ↓ | |||
| New GGN | 21 | 0.2 | 0 | 0.0 | 0–16.1 | ↓ | |||
| Total LR3 | 544 | 5.0 | 4 | 0.7 | 0.2–1.9 | ↓ | |||
| Suspicious | 4A | Solid nodule(s) ⩾ 8 to <15 mm at baseline | 80 | 0.7 | 20 | 25.0 | 16.0–35.9 | 5–15 | ↑ |
| Growing nodule(s) < 8 mm | 23 | 0.2 | 4 | 17.4 | 5.0–38.8 | ↑ | |||
| New solid nodule(s) 6 to <8 mm | 39 | 0.4 | 5 | 12.8 | 4.3–27.4 | √ | |||
| Part solid nodule(s) ⩾ 6 mm w/solid component ⩾ 6 to <8 mm | 10 | 0.1 | 3 | 30.0 | 6.7–65.2 | ↑ | |||
| Part solid nodule(s) w/new or growing <4-mm solid component | 54 | 0.5 | 12 | 22.2 | 12.0–36.0 | ↑ | |||
| Endobronchial nodule(s) | 6 | 0.1 | 1 | 16.7 | 0.4–64.1 | ↑ | |||
| Total LR4A | 212 | 1.9 | 45 | 21.2 | 15.9–27.4 | ↑ | |||
| Very suspicious | 4B | Solid nodule(s) ⩾ 15 mm at baseline | 35 | 0.3 | 25 | 71.4 | 53.7–85.4 | >15 | √ |
| New solid nodule(s) ⩾ 8 mm | 62 | 0.6 | 30 | 48.4 | 35.5–61.4 | √ | |||
| Growing solid nodule(s) ⩾ 8 mm | 39 | 0.4 | 18 | 46.2 | 30.1–62.8 | √ | |||
| Part-solid nodule(s) with solid component ⩾ 8 mm | 8 | 0.1 | 6 | 75.0 | 34.9–96.8 | √ | |||
| Part-solid nodule(s) w/new or growing ⩾ 4 mm solid component | 24 | 0.2 | 12 | 50.0 | 29.1–70.9 | √ | |||
| Total LR4B | 168 | 1.5 | 91 | 54.2 | 46.3–61.9 | √ | |||
| 4X | Lymph nodes ⩾ 15 mm without pulmonary nodules* | 20 | 0.2 | 1 | 5.0 | 0.1–24.9 | N/A | N/A | |
| LR 3 or 4 nodules w/findings increasing cancer risk | 63 | 0.6 | 16 | 25.4 | 15.3–37.9 | >15 | √ | ||
| Total LR4X | 83 | 0.8 | 17 | 20.5 | 12.4–30.8 | √ | |||
Definition of abbreviations: CI = confidence interval; CT = computed tomography; GGN = ground-glass nodules; LR = Lung-RADS v1.1; N/A = not applicable.
*
Not currently part of LR.
†
Unreliable CI.