TABLE 2.
Enzymatic activity of dabrafenib, 14b, 14j and 21c against wild-type BRAF kinase.
| Compound | BRAFwt enzymatic IC50 (nM) |
|---|---|
| Dabrafenib | 2.44 |
| 14b | 4.07 |
| 14j | 3.86 |
| 21c | 2.86 |
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