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. 2022 Apr 20;2(2):100162. doi: 10.1016/j.xops.2022.100162

Figure 3.

Figure 3

Multimodal imaging of the right eye of a 73-year-old woman obtained over a 4-year period: (A–E) baseline visit, (F–J) 2-year follow-up visit, and (K–O) 4-year follow-up visit; (A, F, K) color fundus (CF) images, (B, G, L) near infrared (NIR) images, (C, H, M) fundus autofluorescence (FAF) images, (D, I, N) en face swept-source (SS) OCT images, and (E, J, O) drusen volume maps. A–E, Images obtained at baseline showing soft drusen on the CF image (A, white arrows) that correspond to the drusen on the volume map (E, white arrows). These drusen ultimately became calcified, which was observed at the 2-year and 4-year follow-up visits. F–J, Images obtained at the 2-year visit showing calcified drusen appearing as bright yellow lesions with defined borders containing glistening dots (F, yellow arrows) along with pigment deposits on the CF image. The NIR image (G) shows calcified drusen and pigment deposits appearing as hyperreflective lesions (yellow arrows). The FAF image (H) fails to reliably identify the calcified drusen or pigment deposits. On the en face SS OCT image (I), the calcified drusen and pigment deposits appear as dark areas or hypotransmission defects (yellow arrows). K–O, Images obtained at the 4-year visit showing the formation of more calcified drusen as shown by the blue arrows on the CF (K), NIR (L), and en face SS OCT (N) images.