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. 2022 Apr 20;2(2):100162. doi: 10.1016/j.xops.2022.100162

Figure 5.

Figure 5

Multimodal imaging of the left eye of a 74-year-old woman obtained over a 2-year period: (A–E) baseline visit, (F–J) 1-year follow-up visit, and (K–O) 2-year follow-up visit; (A, F, K) color fundus (CF) images, (B, G, L) near infrared (NIR) images, (C, H, M) fundus autofluorescence (FAF) images, (D, I, N) en face swept-source (SS) OCT images, and (E, J, O) drusen volume maps. A–E, Images obtained at baseline showing a calcified drusen on the CF image (A) as a bright yellow lesion with defined borders (yellow arrow). In addition, the NIR image (B) displays the calcified drusen as a hyperreflective region (yellow arrow). The en face SS OCT image (D) shows this calcified drusen as a hypotransmission defect (hypoTD; yellow arrow). F–J, Images obtained at the 1-year visit showing atrophy forming around the calcified drusen. This is displayed through the FAF image (H) showing patches of hypoautofluorescence (blue arrow). In addition, the en face SS OCT image (I) shows hypertransmission defects (hyperTDs) in the same region (blue arrow). K–O, Images obtained at the 2-year visit, with the FAF image (M) showing hypoautofluorescence in the entire area of the calcified drusen (red arrow), which indicates that the retinal pigment epithelium both above and around the calcified drusen has progressed to atrophy. In contrast, the en face SS OCT image (N) displays only hyperTDs around the lesion (red arrow) because the calcified drusen causes a hypoTD.