Table 3.

Clinical trials of EVs for development of anticancer treatment

Cancer type	Title of the trial	Phase	State	Number of participants	ClinicalTrials.gov identifier
Lung Cancer	Phase II trial of a vaccination with tumor antigen-loaded dendritic cell-derived exosomes on patients with unresectable non-small cell lung cancer responding to induction chemotherapy	II	Completed	41	NCT01159288 [187]
Pancreatic Cancer	Phase I study of mesenchymal stromal cells-derived exosomes with KrasG12D siRNA for metastatic pancreas cancer patients harboring KrasG12D mutation	I	Ongoing	Recruiting	NCT03608631 [186]
Colon Cancer	Phase I clinical trial investigating the ability of plant exosomes to deliver curcumin to normal and malignant colon tissue	I	Ongoing	Recruiting	NCT01294072
Head and Neck Cancer	Preliminary clinical trial investigating the ability of plant exosomes to abrogate oral mucositis induced by combined chemotherapy and radiation in head and neck cancer patients	I	Ongoing	60	NCT01668849