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. 2022 Jul 22;13:961885. doi: 10.3389/fmicb.2022.961885

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Copyright © 2022 Cao, Chen, Xu and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BBr reduces the expression of inflammatory signaling. mRNA expressions of TLR4/NF-kB signaling (A) and inflammatory factor (IL-1β, TNFα, and IL-6; B). (C) Protein expressions of TLR4/NF-kB signaling pathway. Data represent the mean ± SD. P < 0.05 was considered statistically significant. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 vs. CON group.