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. 2022 Jul 22;13:955825. doi: 10.3389/fmicb.2022.955825

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Copyright © 2022 Li, Su, Wang, Liu, Yang, Du, Li, Chen, Xu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Volcano plot showing the contribution of nVFCs in SF3 and CK3 in OPLS-DA. The first data in the brackets is the number of metabolites, the second data are the percentage of each metabolites in the total nVFCs in CK3 and the third data is that in SF3. 1: Prolyl-Valine; 2:LysoPE(0,0/22,0); 3:Enkephaline, (D-Ala)2-Leu; 4: Agavoside A; 5: 6-{[(16S)-5,7-dihydroxy-8,8,12,16-tetramethyl-3-[1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-10-methylidene-9-oxo-17-oxa-4-azabicyclo[14.1.0]heptadec-4-en-11-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid; 6: Gamma-Glutamylphenylalanine; 7: 6-{[(16S)-5,7-dihydroxy-8,8,10,16-tetramethyl-3-[1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-12-methylidene-9-oxo-17-oxa-4-azabicyclo[14.1.0]heptadec-4-en-11-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid; 8: Asp-Phe; 9: Physagulin D; 10: (+/−)-Hexanoylcarnitine; 11: Isoleucyl-Leucine; 12: Adenosine 3′-monophosphate; 13: PS(MonoMe(11,5)/MonoMe(11,3)); 14: Uridine diphosphate-N-acetylglucosamine; 15: Physapruin B; 16: 7a-Hydroxy-5b-cholanic acid; 17: Isoleucyl-Isoleucine; 18: Isoleucyl-Tyrosine; 19: Digalacturonate; 20: 2,10-Bisaboladiene-1,4-diol; 21: (+/−)-Octanoylcarnitine; 22: Isoleucyl-Alanine; 23: 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H-1-benzopyran-4-one; 24: N-(2-Phenylethyl)-acetamide; 25: L-cis-Cyclo(aspartylphenylalanyl); 26: Leucyl-Alanine; 27: Sulfolithocholylglycine; 28: Curcumadiol; 29: Caryoptosidic acid; 30: Ascorbyl stearate; 31: Acetylcholine; 32: 1-Methylhypoxanthine.