TABLE 1.
Comparison of clinical and demographic characteristics between patients with MDD and HCs, responders, and non-responders.
| Group | MDD (n = 63) |
HCs (n = 30) |
p-value | Responders (n = 36) |
Non-responders (n = 27) |
p-value |
| Age (years, mean ± SD) | 28.34 ± 8.63 | 29.23 ± 6.59 | 0.621 | 29.86 ± 8.02 | 26.33 ± 9.14 | 0.109 |
| Sex, n (%) | 0.878 | |||||
| Male | 20 (31.7) | 10 (33.3) | 10 (27.8) | 10 (37.0) | ||
| Female | 43 (68.3) | 20 (66.7) | 26 (72.2) | 17 (63.0) | ||
| Marital status, n (%) | 0.954 | 0.080 | ||||
| Single | 29 (46.0) | 14 (46.7) | 20 (55.6) | 9 (33.3) | ||
| Married | 34 (54.0) | 16 (53.3) | 16 (44.4) | 18 (66.7) | ||
| Family history, n (%) | ||||||
| Yes | 12 (19.0) | NA | 7 (19.4) | 5 (18.5) | 0.926 | |
| No | 51 (81.0) | NA | 29 (80.6) | 26 (81.5) | ||
| BMI (mean ± SD) | 21.67 ± 3.91 | 21.49 ± 2.23 | 0.815 | 21.93 ± 3.70 | 21.33 ± 4.23 | 0.554 |
| Smoking | 0.389 | |||||
| Yes | 11 (17.5) | 7 (23.3) | 0.503 | 5 (13.9) | 6 (22.2) | |
| No | 52 (82.5) | 23 (76.7) | 31 (86.1) | 21 (77.8) | ||
| Drinking | 0.195 | |||||
| Yes | 22 (34.9) | 6 (20.0) | 15 (41.7) | 7 (25.9) | ||
| No | 41 (65.1) | 24 (80.0) | 0.143 | 21 (58.3) | 20 (74.1) | |
| HAMD baseline | 28.31 ± 7.58 | NA | 26.94 ± 7.73 | 30.14 ± 7.11 | 0.097 | |
| HAMA baseline | 18.75 ± 7.79 | NA | 20.06 ± 8.84 | 17.00 ± 5.84 | 0.125 | |
| Antidepressant# (mg/day) | 42.33 ± 11.88 | NA | 43.04 ± 11.15 | 41.39 ± 12.94 | 0.589 |
HAMD, Hamilton Depression Rating Scale; HAMA, Hamilton Anxiety Rating Scale; NA, not applicable; MDD, major depressive disorder; HCs, healthy controls; SD, standard deviation; BMI, body mass index.
#Fluoxetine-equivalent dose of antidepressant medication.