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. 2022 Jul 22;9:905049. doi: 10.3389/fsurg.2022.905049

Figure 1.

Figure 1

Interaction between epithelial cells, junctional proteins and microbiota on intestinal wound healing to restore mucosal homeostasis. Following epithelial injury, proteins such as CD44v6 or CD47 are upregulated at epithelial cells adjacent to the wound. In addition, luminal microbes are in close contact with intact epithelial cells. As a result, cell proliferation and migration is controlled and supported by the presented pathways to restore epithelial linings.